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Nemifitide diTFA

Name: Nemifitide diTFA
Brand: TargetMol
SKU: TP1127
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1127Cas No. 204992-09-6

Alias INN 00835 diTFA

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide that can cross the blood-brain barrier and acts as a potent antidepressant, similar to melanocyte suppressor factor (MIF).

Nemifitide diTFA

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Purity: 99.84%

Catalog No. TP1127Alias INN 00835 diTFACas No. 204992-09-6

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide that can cross the blood-brain barrier and acts as a potent antidepressant, similar to melanocyte suppressor factor (MIF).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	-	In Stock
5 mg	$207	-	In Stock
10 mg	$373	-	In Stock
25 mg	$635	-	In Stock
50 mg	$950	-	In Stock
100 mg	$1,430	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide that can cross the blood-brain barrier and acts as a potent antidepressant, similar to melanocyte suppressor factor (MIF).
In vitro	Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind to multiple receptors, including 5-HT2A, 5-HT2C, melanocortin MC4, MC5, and bombesin, at micromolar concentrations[2].
In vivo	Administered intraperitoneally at a dose of 0.3 mg/kg daily for 14 days, Nemifitide diTFA (INN 00835 diTFA) significantly increases swimming behavior in the FSL rats after just 5 days of treatment, and this effect has a long-lasting duration[2]. Moreover, across a range of doses (0.0125-15.0 mg/kg), Nemifitide diTFA demonstrates a significant increase in swimming behavior in FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses, but not at intermediate (0.4-2.4 mg/kg) doses[3].
Synonyms	INN 00835 diTFA

Chemical Properties

Molecular Weight	922.8
Formula	C₃₇H₄₅F₇N₁₀O₁₀
Cas No.	204992-09-6
Smiles	OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Relative Density.	no data available
Sequence	4-fluoro-L-phenylalanyl-(4R)-4-hydroxy-L-prolyl-L-arginyl-glycyl-L-tryptophanamide
Sequence Short	XXRGW

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (216.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0837 mL	5.4183 mL	10.8366 mL	54.1829 mL
5 mM	0.2167 mL	1.0837 mL	2.1673 mL	10.8366 mL
10 mM	0.1084 mL	0.5418 mL	1.0837 mL	5.4183 mL
20 mM	0.0542 mL	0.2709 mL	0.5418 mL	2.7091 mL
50 mM	0.0217 mL	0.1084 mL	0.2167 mL	1.0837 mL
100 mM	0.0108 mL	0.0542 mL	0.1084 mL	0.5418 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc